September 29, 2005
— Dr. Reo Symes Crazy.
Genetically altered mice discovered accidentally at the Wistar Institute in Pennsylvania have the seemingly miraculous ability to regenerate like a salamander, and even regrow vital organs.The article even has nice pictures of a mouses ear with a pretty good size hole (I dunno, maybe baseballish were the mouse man size) just healing itself up. No scars.
Researchers systematically amputated digits and damaged various organs of the mice, including the heart, liver and brain, most of which grew back.
The results stunned scientists because if such regeneration is possible in this mammal, it might also be possible in humans.
The researchers also made a remarkable second discovery: When cells from the regenerative mice were injected into normal mice, the normal mice adopted the ability to regenerate. And when the special mice bred with normal mice, their offspring inherited souped-up regeneration capabilities.
You know, I read stuff like this about every two weeks it seems. Not the same story, just researchers somewhere doing something so mindblowing, the only way to deal with it is to pretend its Sci-Fi or that i didn't read it. Stuff that calls into question too many assumptions hard wired into my brain.
Posted by: djs at September 29, 2005 08:00 PM (xTnlx)
Oh yeah, and I'm willing to bet there will be a fat, fat DARPA grant in these folks' future.
Posted by: Bravo Romeo Delta at September 29, 2005 08:25 PM (kiA+F)
Think of the implications this could have for anti-aging therapy!
Posted by: Desert Cat at September 29, 2005 08:30 PM (xdX36)
Posted by: at September 29, 2005 08:35 PM (52h84)
Posted by: at September 29, 2005 08:36 PM (52h84)
It does seem like there's something like this every few weeks, probably because there is something like this every few weeks. I linked a very similar story on Sept. 2nd, but a totally different group of scientist.
Posted by: at September 29, 2005 08:46 PM (ipjUv)
Oops! You thinking about having something cut off, Doc?
Posted by: at September 29, 2005 09:25 PM (52h84)
Posted by: Purple Avenger at September 29, 2005 09:38 PM (X+OCl)
Posted by: Ben Zeen (a pseudonym) at September 29, 2005 10:22 PM (ajOQw)
Heck I cought a rat in one of those traps a few years ago - he nibbled at just the right angle and it snapped his neck cleanly.
The original Victor trap is a truly amazing device. I have full confidence in its ability to deal with all current and future mice.
The trick is to forget about the old "mice like cheese thing" -- that's a crock of shit. Mice are hopeless genetic suckers for peanut butter. They simply can't resist it. Kinda like Ted Kennedy and Chivas or Crown Royal - one whiff and they're done.
Posted by: Purple Avenger at September 29, 2005 10:33 PM (X+OCl)
Posted by: The Unabrewer at September 30, 2005 02:36 AM (AXzo0)
I mean, really, for every discovery like this that you actually hear about, there's probably 15 happening at Universities around the world that you don't hear about. It just takes so freaking long for stuff to leave a laboratory and actually make it to the market.
Posted by: Hal at September 30, 2005 02:45 AM (E1PhK)
Posted by: Mikey at September 30, 2005 02:48 AM (O9Cc8)
DARPA is in fact working on a project to do exactly this, with the goal of regrowing limbs blown off in combat.
Posted by: Bill from INDC at September 30, 2005 02:54 AM (nWGiI)
Posted by: Jordan at September 30, 2005 02:56 AM (S0KP/)
Posted by: Steve L. at September 30, 2005 03:51 AM (hpZf2)
Posted by: John at September 30, 2005 03:57 AM (wg4FW)
Posted by: lauraw at September 30, 2005 04:40 AM (0XkF8)
But seriously, I always figured that to properly grow a limb back you'd have to have some kind of electrochemical 'blueprint' to teach the cells to grow in the proper direction, a kind of electrical lattice for them to follow.
So anyway, that is truly neat, but the tumor thing is something I'd be worried about too.
Posted by: Fox at September 30, 2005 04:44 AM (1ZP5A)
Posted by: Arnold Schwarzenegger at September 30, 2005 04:46 AM (pzen5)
Posted by: SparcVark at September 30, 2005 04:47 AM (X7hb0)
Posted by: tom scott at September 30, 2005 05:33 AM (QfvmC)
Well, the original mice have their DNA modified, permanent. The other mice have some of the DNA injected into their bodies, giving them regeneration effects. In certain gene therapy vector design, a variation of the second method would be a controlled, transient exposure to the effect of the gene therapy; it would wear off.
Posted by: Bill fom INDC at September 30, 2005 05:39 AM (yZMsp)
Hey, the Garden of Eden called, they want their apple back.
Yeah - the key question here is, does the regrown "limb" turn out exactly the same as the old one, or could it be, you know, a different size, maybe, just for the sake of argument, bigger?
Yeah, I want bigger AND prehensile! Just think of the "kitchee kitchee koo!" you could deliver at the right moment!
Posted by: The Claw at September 30, 2005 06:07 AM (74cXW)
Posted by: Josh at September 30, 2005 07:57 AM (S6Wcf)
Then all the signalling factors that were responsible for the embryonic blueprint (FGF's, Hox genes) are activated at once. Different amounts of the genes are activated according to whether they are on the right or left, or the base or tip of the limb. This makes a gradient of signals that controls the growth. The blueprint for the end of the limb (the hand or foot) is laid down first, then the middle part is filled in.
Posted by: Axolotl at September 30, 2005 03:37 PM (7NBwW)
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